‘ ‘ Expression of Globo H and SSEA 3 in breast cancer

نویسندگان

  • Wen-Wei Chang
  • Chien Hsin Lee
  • Peishan Lee
  • Juway Lin
  • Chun-Wei Hsu
  • Jung-Tung Hung
  • Jin-Jin Lin
  • Jyh-Cherng Yu
  • Li-en Shao
  • John Yu
  • Chi-Huey Wong
  • Alice L. Yu
  • Jeffrey S. Martini
  • Philip Raake
  • Leif E. Vinge
  • Brent DeGeorge
  • Kurt Chuprun
  • David M. Harris
  • Erhe Gao
  • Andrea D. Eckhart
  • Julie A. Pitcher
  • Brent R. DeGeorge
  • Walter J. Koch
  • Jan Martel
چکیده

in breast cancer stem cells and the involvement of fucosyl transferases 1 and 2 in Globo H synthesis,’’ by Wen-Wei Chang, Chien Hsin Lee, Peishan Lee, Juway Lin, Chun-Wei Hsu, Jung-Tung Hung, Jin-Jin Lin, Jyh-Cherng Yu, Li-en Shao, John Yu, Chi-Huey Wong, and Alice L. Yu, which appeared in issue 33, August 19, 2008, of Proc Natl Acad Sci USA (105:11667–11672; first published August 6, 2008; 10.1073 pnas.0804979105), the authors note that in the Abstract, line 8, ‘‘29/31’’ should have appeared as ‘‘29/40.’’ Additionally, in Table 1, last column, second row from the bottom, ‘‘77.5’’ should have appeared as ‘‘72.5.’’ These errors do not affect the conclusions of the article. The corrected table appears below. MEDICAL SCIENCES. For the article ‘‘Uncovering G protein-coupled receptor kinase-5 as a histone deacetylase kinase in the nucleus of cardiomyocytes,’’ by Jeffrey S. Martini, Philip Raake, Leif E. Vinge, Brent DeGeorge, Jr., J. Kurt Chuprun, David M. Harris, Erhe Gao, Andrea D. Eckhart, Julie A. Pitcher, and Walter J. Koch, which appeared in issue 34, August 26, 2008, of Proc Natl Acad Sci USA (105:12457–12462; first published August 18, 2008; 10.1073 pnas.0803153105), the authors note that the author name Brent DeGeorge, Jr., should have appeared as Brent R. DeGeorge, Jr. The author line has been corrected online. The corrected author line and related author contributions footnote appear below.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Stage-specific embryonic antigen-3 (SSEA-3) and β3GalT5 are cancer specific and significant markers for breast cancer stem cells.

The discovery of cancer stem cells (CSCs), which are responsible for self-renewal and tumor growth in heterogeneous cancer tissues, has stimulated interests in developing new cancer therapies and early diagnosis. However, the markers currently used for isolation of CSCs are often not selective enough to enrich CSCs for the study of this special cell population. Here we show that the breast CSCs...

متن کامل

Synthesis of Complex Glycosphingolipids of the Globo Series

Versatile strategies were designed for the synthesis of biologically important glycosphingolipids of the globo series, as illustrated for the synthesis of the hexasaccharide of the human breast cancer antigen (Globo H, MBr1) and of the stage-specific embryonic antigen 4 (SSEA-4, Sialylgalactosylgloboside).

متن کامل

Affinity of monoclonal antibodies for Globo-series glycans.

Globo-series glycans are human cell-surface carbohydrates that include stem-cell marker SSEA-4 and cancer-cell antigen Globo H. These two hexasaccharides differ only in their terminal saccharide: N-acetylneuraminic acid in SSEA-4 and L-fucose in Globo H. Herein, we evaluated the affinity of the monoclonal antibodies α-SSEA-4 and α-GH for the glycans SSEA-4 and Globo H. Using fluorescence polari...

متن کامل

Glycan microarray of Globo H and related structures for quantitative analysis of breast cancer.

Cancer-associated carbohydrate antigens are often found on the surface of cancer cells. Understanding their roles in cancer progression will lead to the development of new therapeutics and high-sensitivity diagnostics for cancers. Globo H is a member of this family, which is highly expressed on breast cancer cells. Here, we report the development of a glycan microarray of Globo H and its analog...

متن کامل

Effect of Boswellia Thurifera Gum Methanol Extract on Cytotoxicity and P53 Gene Expression in Human Breast Cancer Cell Line

Abstract Boswellia has been widely used in traditional medicine for the treatment of different diseases such as cancer in Iran. The aim of this study was to evaluate the effect of the gum methanol extract of Boswellia thurifera on the viability and P53 gene expression of cultured breast cancer cells. The gum methanol extract was obtained in various concentrations using the maceration method. No...

متن کامل

Effect of Boswellia Thurifera Gum Methanol Extract on Cytotoxicity and P53 Gene Expression in Human Breast Cancer Cell Line

Abstract Boswellia has been widely used in traditional medicine for the treatment of different diseases such as cancer in Iran. The aim of this study was to evaluate the effect of the gum methanol extract of Boswellia thurifera on the viability and P53 gene expression of cultured breast cancer cells. The gum methanol extract was obtained in various concentrations using the maceration method. No...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2008